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On its way to the unchartered Phoenix cluster


January 28th, 2018

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The serotonin transporter, encoded by the SLC6A4 gene, influences the synaptic actions of serotonin and is responsive to stress hormones. We hypothesized that 5 HTTLPR, a functional SLC6A4 promoter polymorphism, and two tightly linked, putatively functional 3′ UTR SNPs (rs3813034, rs1042173) might have independent effects on suicidal behavior in the context of childhood trauma (CT). DNA and Childhood Trauma Questionnaire scores were available for a total of 474 African Americans, including 112 suicide attempters and 362 non suicide attempters.

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